In pediatrics, what counts as “normal” depends on age and development — so we start here.
These details stay on this device and are de-identified (no names or identifiers); they
choose which screen applies and how each item is interpreted.
Reference aid only. This pediatric tool supports — and does not replace —
clinical judgment, local protocol, and prescriber/pharmacy review. It is not a validated
decision-support device or an order set. Pharmacologic content is off-label and
limited-evidence; verify every weight-based dose against your institution's formulary.
Child context
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Enter the child's age to continue.
Screen
Reference aid only. This pediatric tool supports — and does not replace
— clinical judgment, local protocol, and prescriber/pharmacy review. It is not a
validated decision-support device or an order set. Pharmacologic content is off-label
and limited-evidence; verify every weight-based dose against your institution's
formulary.
1 · Arousal — the screening gate
Score arousal first. RASS −4/−5 (or SBS −2/−3) = comatose → record
unable to assess; screen only once the child responds to voice (RASS
≥ −3 / SBS ≥ −1). SBS is the pediatric arousal scale for intubated infants and young
children.
Arousal level
2 · CAPD — Cornell Assessment of Pediatric Delirium
Rate the child over the shift against age-expected behavior. Eight items, 0–4
each (0–32 total); ≥ 9 = positive.
2 · pCAM-ICU / psCAM-ICU features
Delirium is present when Feature 1 and Feature 2 are present
and (Feature 3 or Feature 4).
pCAM-ICU (≥ 5 yr): verbal attention and command tasks.psCAM-ICU (6 mo–5 yr): age-adapted observational tasks.
Result
Select an arousal level to begin.
References
Pediatric ICU delirium — risk factors
PICU delirium is common (point prevalence ~25%; higher with mechanical ventilation and
developmental delay) and is mostly hypoactive or mixed — easily missed. This is a
review aid summarizing reported associations, not a validated predictive
score. Minimizing the modifiable factors — benzodiazepines above all — is the actionable
lever. Factors your child profile already implies are flagged automatically; check any
others that apply.
Modifiable levers: prefer dexmedetomidine over benzodiazepines;
deprescribe anticholinergics; target light, goal-directed sedation; mobilize early;
minimize restraints; protect sleep and maximize family presence.
Non-pharmacologic, multicomponent prevention is first-line; routine
pharmacologic prophylaxis (e.g., scheduled antipsychotics) is
not recommended. Bundle benefit is best established for mortality and
care-process measures, while a direct drop in delirium incidence from bundle adoption
alone has been inconsistent — but the individual levers (benzodiazepine minimization
above all) are well supported. Check
each element addressed this shift.
The bundle (A–F)
Non-pharmacologic measures
Sleep aids: melatonin and other pharmacologic sleep aids are not
established for delirium prevention in children — use non-pharmacologic sleep hygiene
first.
References
Treatment — a stepwise pathway
Delirium treatment is mostly non-pharmacologic. Drugs treat symptoms
(short-term, refractory agitation that threatens safety), never the delirium itself,
and no agent is FDA-approved for pediatric delirium. Weight-based starting doses are
in
Medications.
Step 1 — Treat the cause & apply the bundle (first-line)
Find and fix precipitants. Optimize analgesia; switch benzodiazepine sedation to
dexmedetomidine; deprescribe anticholinergics; restore sleep and day–night rhythm;
mobilize early; maximize family presence; and assess for iatrogenic withdrawal
(WAT-1). This is the treatment — drugs are adjunctive.
Step 2 — If agitation threatens safety and non-pharm has failed
Consider a short course of an antipsychotic at the lowest effective
dose, reassessed daily. PANDEM names haloperidol or an atypical without preferring
either; in reported PICU practice the
atypicals (risperidone, quetiapine, olanzapine) are usually chosen first — a
prescribing-pattern and safety-profile preference, not a guideline ranking. See Medications for
weight-based starting doses.
Off-label, limited evidence. No pediatric randomized trial supports
antipsychotics for PICU delirium; the data are retrospective and observational, and a
large database study linked antipsychotic use to higher mortality (confounded by
indication). Use the lowest dose for the shortest time.
Step 3 — Reserve IV haloperidol
Reserving IV haloperidol for when an enteral agent isn't feasible is an
expert-practice choice — PANDEM ranks no agent, and for small children who are NPO, IV haloperidol is among the options its
reviewers name. It carries higher QTc /
torsades and EPS / acute-dystonia risk than the atypicals — continuous ECG, correct K
/ Mg, and have IV diphenhydramine or benztropine ready.
Before & during any antipsychotic — monitoring
Baseline 12-lead ECG (QTc), electrolytes (K, Mg, Ca), and review of
concurrent QT-prolonging drugs (ondansetron, methadone, macrolides, azoles, certain
antiarrhythmics). Read the QTc against
age-, sex-, rhythm- and correction-formula-appropriate limits: the
normal upper limit is < 450 ms in children 11 days to 16 years
(after puberty adult limits diverge by sex; Bazett is unreliable in tachycardia and
with conduction abnormalities). Treat a borderline or prolonged result as a prompt to
repeat / verify the ECG, correct electrolytes, and review interacting drugs;
QTc ≥ 500 ms, or a clear rise from this patient's own baseline,
warrants urgent prescriber / pharmacy review and management under the local cardiology
or medication-safety protocol, which sets the stop / reduce thresholds. Watch for
acute dystonia / EPS (most with haloperidol — treat with IV diphenhydramine or
benztropine), akathisia, and NMS (fever, rigidity, autonomic instability, ↑ CK). Over
longer courses, watch weight gain and metabolic change (highest with olanzapine and
quetiapine).
References
Not an order set. Pharmacologic content is off-label and
limited-evidence. Doses below are weight-based starting points from the pediatric
literature —
verify every dose against your institution's formulary and a current pediatric
reference (Lexicomp Pediatric / Harriet Lane) before prescribing.
Sedation & sleep
Agent
Pediatric dose
Notes
Dexmedetomidinepreferred
0.2–1 mcg/kg/hr IV infusion, titrated to a light goal; a loading bolus is
often omitted in the PICU to limit hemodynamic effects.
Delirium-sparing — preferred over benzodiazepines. Bradycardia, hypotension
(biphasic BP); caution in cardiac disease / AV block. Rebound
agitation/hypertension if stopped abruptly after prolonged use — taper. Not a
substitute for analgesia (opioid-sparing at most) or reliable amnesia. PICU
continuous sedation is off-label; the only FDA-labeled pediatric use is
procedural sedation of non-intubated children ≥ 1 month.
Benzodiazepines (midazolam, lorazepam)
Limit / avoid as continuous sedation.
Independent, dose-related delirium risk. Do not escalate to treat
delirium-related agitation. Reserve for specific indications (status
epilepticus, sedative / alcohol withdrawal, procedural need).
Melatonin
0.5–3 mg PO at bedtime (younger); up to 3–5 mg (older children / adolescents)
— general pediatric sleep dosing.
Sleep / circadian support — not a delirium treatment. Limited pediatric ICU
evidence (delirium-prevention data are adult-ICU only). Confirm product (immediate- vs extended-release).
Start low and titrate, by age / weight band.
≤ 2 yr ~0.01–0.04 mg/kg/day (mean ~0.02) — studied only in a
17-patient cohort; verify every dose with a pediatric pharmacist. < 5 yr ~0.1 mg q12–24h; ≥ 5 yr ~0.2 mg
q12–24h. No single daily maximum
spans infants to adolescents — set the ceiling from a named institutional
protocol or formulary for the child's age and weight.
Often first-line oral. QTc (least among atypicals — still monitor), EPS /
dystonia, hyperprolactinemia, sedation, metabolic. Baseline + follow-up ECG.
Prominent sedation and metabolic / weight gain; anticholinergic effects; QTc.
Haloperidolreserve
Reserve for severe agitation when an enteral antipsychotic isn't feasible. IV
is off-label; use it
only under a current institutional pediatric agitation / delirium
protocol. That protocol must specify age- and weight-based eligibility, route, the
repeat interval, a maximum cumulative loading dose and a
maximum daily dose, ECG / electrolyte monitoring,
contraindications, and the treatment of acute dystonia. No generic loading or
maintenance dose is shown here — the published pediatric data are a few small
case series whose loading totals and intervals differ several-fold, so a numeric range without those protocol bounds would be unsafe. Oral
liquid available.
High caution. Dose-dependent QTc prolongation / torsades —
continuous ECG, correct K / Mg; IV use carries an FDA torsades warning. More
EPS / acute dystonia than atypicals in children (have IV diphenhydramine /
benztropine ready). NMS; lowers seizure threshold. Avoid in long-QT,
significant hepatic impairment, Parkinsonism.
Deliriogenic medications — review & minimize
Benzodiazepines (strongest modifiable risk) · centrally penetrating anticholinergics
(especially diphenhydramine, atropine, scopolamine) — glycopyrrolate is a quaternary
amine with limited CNS penetration, so weigh its peripheral effects and the overall
medication burden rather than treating it as equivalent · high or escalating opioids
(analgesia first, but cumulative dose is a risk) · corticosteroids (dose-related
neuropsychiatric effects) · other CNS-acting / GABAergic agents.
References
Verify every weight-based dose against a current pediatric reference (Lexicomp Pediatric
/ Harriet Lane) and your institution's formulary.
Institution & unit
Facility-level settings — they persist on this device and print on the report, and are
kept when you start a new child.
Pediatric approvals
PICU governance roles. Unlike adult units (medical director + nursing), pediatric
units add a pediatric pharmacist sign-off for the off-label
weight-based dosing.
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Generate Documents
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flagged risks, medications given, and your unit governance — generated on this device.
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The report prints these as Assessed (time and clinician), alongside
Generated
(when you create it); the file is named with the generation timestamp.
Enter a child and record an arousal level first.
Medications given this shift
Check any agents in use — they print on the report with their starting dose.