In pediatrics, what counts as “normal” depends on age and development — so we start here.
These details stay on this device and are de-identified (no names or identifiers); they
choose which screen applies and how each item is interpreted.
Reference aid only. This pediatric tool supports — and does not replace —
clinical judgment, local protocol, and prescriber/pharmacy review. It is not a validated
decision-support device or an order set. Pharmacologic content is off-label and
limited-evidence; verify every weight-based dose against your institution's formulary.
Child context
Enter the child's age to continue.
Screen
1 · Arousal — the screening gate
Score arousal first. RASS −4/−5 (or SBS −3) = comatose → record
unable to assess; screen only once the child responds to voice (RASS
≥ −3). SBS is the pediatric arousal scale for intubated infants and young children.
Arousal level
2 · CAPD — Cornell Assessment of Pediatric Delirium
Rate the child over the shift against age-expected behavior. Eight items, 0–4
each (0–32 total); ≥ 9 = positive.
2 · pCAM-ICU / psCAM-ICU features
Delirium is present when Feature 1 and Feature 2 are present
and (Feature 3 or Feature 4).
pCAM-ICU (≥ 5 yr): verbal attention and command tasks.psCAM-ICU (6 mo–5 yr): age-adapted observational tasks.
Result
Select an arousal level to begin.
References
Pediatric ICU delirium — risk factors
PICU delirium is common (point prevalence ~25%; higher with mechanical ventilation and
developmental delay) and is mostly hypoactive or mixed — easily missed. This is a
review aid summarizing reported associations, not a validated predictive
score. Minimizing the modifiable factors — benzodiazepines above all — is the actionable
lever. Factors your child profile already implies are flagged automatically; check any
others that apply.
Modifiable levers: prefer dexmedetomidine over benzodiazepines;
deprescribe anticholinergics; target light, goal-directed sedation; mobilize early;
minimize restraints; protect sleep and maximize family presence.
References
Clinical values carry a pediatric-clinician sign-off gate.
Non-pharmacologic, multicomponent prevention is first-line; routine
pharmacologic prophylaxis (e.g., scheduled antipsychotics) is not
recommended. Honest framing: bundle benefit is best established for mortality and
care-process measures, while a direct drop in delirium incidence from bundle adoption
alone has been inconsistent — but the individual levers (benzodiazepine minimization
above all) are well supported. Check each element addressed this shift.
The bundle (A–F)
Non-pharmacologic measures
Sleep aids: melatonin and other pharmacologic sleep aids are not
established for delirium prevention in children — use non-pharmacologic sleep hygiene
first.
References
Clinical values carry a pediatric-clinician sign-off gate.
Treatment — a stepwise pathway
Delirium treatment is mostly non-pharmacologic. Drugs treat symptoms
(short-term, refractory agitation that threatens safety), never the delirium itself,
and no agent is FDA-approved for pediatric delirium. Weight-based starting doses are
in
Medications.
Step 1 — Treat the cause & apply the bundle (first-line)
Find and fix precipitants. Optimize analgesia; switch benzodiazepine sedation to
dexmedetomidine; deprescribe anticholinergics; restore sleep and day–night rhythm;
mobilize early; maximize family presence; and assess for iatrogenic withdrawal
(WAT-1). This is the treatment — drugs are adjunctive.
Step 2 — If agitation threatens safety and non-pharm has failed
Consider a short course of an atypical antipsychotic (risperidone,
quetiapine, or olanzapine — generally preferred over haloperidol) at the lowest
effective dose, reassessed daily. See Medications for weight-based
starting doses.
Off-label, limited evidence. No pediatric randomized trial supports
antipsychotics for PICU delirium; the data are retrospective and observational, and a
large database study linked antipsychotic use to higher mortality (confounded by
indication). Use the lowest dose for the shortest time.
Step 3 — Reserve IV haloperidol
Reserve IV haloperidol for severe agitation when enteral atypicals aren't feasible. It
carries higher QTc / torsades and EPS / acute-dystonia risk than the atypicals —
continuous ECG, correct K / Mg, and have IV diphenhydramine or benztropine ready.
Before & during any antipsychotic — monitoring
Baseline 12-lead ECG (QTc), electrolytes (K, Mg, Ca), and review of
concurrent QT-prolonging drugs (ondansetron, methadone, macrolides, azoles, certain
antiarrhythmics). Act on QTc > 450–500 ms or a
≥ 25% rise from baseline (closer monitoring, dose reduction, or
stop). Watch for acute dystonia / EPS (most with haloperidol — treat with IV
diphenhydramine or benztropine), akathisia, and NMS (fever, rigidity, autonomic
instability, ↑ CK). Over longer courses, watch weight gain and metabolic change
(highest with olanzapine and quetiapine).
References
Clinical values carry a pediatric-clinician sign-off gate.
Not an order set. Pharmacologic content is off-label and
limited-evidence. Doses below are weight-based starting points from the pediatric
literature —
verify every dose against your institution's formulary and a current pediatric
reference (Lexicomp Pediatric / Harriet Lane) before prescribing.
Sedation & sleep
Agent
Pediatric dose
Notes
Dexmedetomidinepreferred
0.2–1 mcg/kg/hr IV infusion, titrated to a light goal; a loading bolus is
often omitted in the PICU to limit hemodynamic effects.
Delirium-sparing — preferred over benzodiazepines. Bradycardia, hypotension
(biphasic BP); caution in cardiac disease / AV block. Rebound
agitation/hypertension if stopped abruptly after prolonged use — taper. No
analgesia or amnesia. Off-label < 18 yr.
Benzodiazepines (midazolam, lorazepam)
Limit / avoid as continuous sedation.
Independent, dose-related delirium risk. Do not escalate to treat
delirium-related agitation. Reserve for specific indications (status
epilepticus, sedative / alcohol withdrawal, procedural need).
Melatonin
0.5–3 mg PO at bedtime (younger); up to 3–5 mg (older children / adolescents).
Sleep / circadian support — not a delirium treatment. Limited pediatric ICU
evidence. Confirm product (immediate- vs extended-release).
Prominent sedation and metabolic / weight gain; anticholinergic effects; QTc.
Haloperidolreserve
Reserve for severe agitation when enteral atypicals aren't feasible. IV
(off-label): load ~0.025–0.1 mg/kg/dose, may repeat; maintenance ~0.015–0.15
mg/kg/dose IV q6–8h. Oral liquid available.
High caution. Dose-dependent QTc prolongation / torsades —
continuous ECG, correct K / Mg; IV use carries an FDA torsades warning. More
EPS / acute dystonia than atypicals in children (have IV diphenhydramine /
benztropine ready). NMS; lowers seizure threshold. Avoid in long-QT,
significant hepatic impairment, Parkinsonism.
Deliriogenic medications — review & minimize
Benzodiazepines (strongest modifiable risk) · anticholinergics (diphenhydramine,
atropine / glycopyrrolate, scopolamine) · high or escalating opioids (analgesia first,
but cumulative dose is a risk) · corticosteroids (dose-related neuropsychiatric
effects) · other CNS-acting / GABAergic agents.
References
Weight-based values must map to Lexicomp Pediatric / Harriet Lane (edition pinned at
sign-off). All doses carry a pediatric-clinician + pharmacist sign-off gate.
Institution & unit
Facility-level settings — they persist on this device and print on the report, and are
kept when you start a new child.
Pediatric approvals
PICU governance roles. Unlike adult units (medical director + nursing), the off-label
weight-based dosing carries a pediatric pharmacist sign-off.
Settings also auto-save in this browser.
Generate Documents
A one-page, de-identified summary of this assessment — child context, screen result,
flagged risks, medications given, and your unit governance — generated on this device.
No data leaves the browser.
The report prints these as Assessed (time and clinician), alongside
Generated
(when you create it); the file is named with the generation timestamp.
Enter a child and record an arousal level first.
Medications given this shift
Check any agents in use — they print on the report with their starting dose.